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In the Phase 2 obesity trial, which followed adults with obesity or overweight for 48 weeks, the average reductions in body weight were striking: To put that in perspective, at the 12 mg dose, more than eight in ten participants lost at least 15% of their starting body weight

Common sites for transdermal medication delivery include the upper outer arm, upper chest, upper back between the shoulder blades, and the abdomen (avoiding the waistline)

While stopping abruptly isn't dangerous medically, a gradual taper often produces fewer rebound symptoms and better long-term results

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The patch was then inspected visually and under a microscope before use

The 6-day half-life is the technical reason for once-weekly dosing