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Generally, it will take around 4-8 weeks for you to notice significant changes

[14] [15] Heart rate changes: GLP-1 receptor agonists are associated with a modest increase in resting heart rate

In clinical trials investigating retatrutide, a dose-escalation approach has been used to minimise gastrointestinal side effects and improve tolerability

The amount of weight lost will depend on factors such as adherence to the medication schedule, dietary habits, and physical activity