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doi.org/10.1093/humupd/dmt037 Wang T, Babayev E, Jiang Z, et al

In sum, it is worthy to note that lipid peroxidation (LPO) products such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) arise as secondary messengers of oxidative stress, which is often counterbalanced by the cellular antioxidant defense system [133]

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It is a naturally occurring compound, not a banned or controlled substance