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In animal models of neurodegenerative disease, activation of TGR5 receptor was neuroprotective, decreasing neuronal death and inflammatory response (Monteiro-Cardoso et al., 2021)

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However, the mechanism underlying brain abnormalities in NPSLE remains largely unknown, and effective strategies to ameliorate neuropsychiatric disorders are limited

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Retatrutide will almost certainly fall in a similar range, possibly slightly higher given the additional receptor target and superior efficacy data