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Am J Emerg Med 2024:78:89-94

Retatrutide is not yet FDA approved, but like many GLP-1 agonists such as Wegovy (semaglutide) and Mounjaro (tirzepatide), retatrutide will most likely be a weekly injection, delivered subcutaneously into the arm, thigh or stomach area in a self-inject pen

L.ZeffiroT.HaslerG.et al (2014)

Figure 2: AMPA and NMDA receptor levels following 40 ng/ml dose of IGF-1 DES

Part of the discrepancy may reflect prescribing outside the NHS

These findings emphasize the importance of systemic vascular function and mechanics on long term brain health, likely mediated by damage and mechanical stress on cerebral microvasculature