[5] [16] This multi-receptor activity drives significant reductions in appetite, caloric intake, and body weight effects that, while therapeutically promising, can also influence how the body regulates temperature
On the other hand, some side effects of semaglutidelike nausea, fatigue, or digestive issuesmight reduce interest in sex, especially early in treatment
Since many of the adverse events and discontinuations occurred before maintenance doses were achieved, Nauck and Horowitz suggest that the priority may be to find ways to improve tolerability of oral GLP-1 RAs, including by exploring dose-escalation regimens
Individuals with a history of pancreatitis should use these medications with caution, if at all
Because this work examines direct TAM effects on experimental endpoints only in the context of neurogenesis research in adult animals, further testing is needed to determine the suitability of alternate TAM dosing methods for subadult animals and research on other brain processes
GLP-1 receptors are present on pancreatic ductal cells, and animal studies suggested potential proliferative effects
