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Stakeholders in the compounding supply chain should monitor these developments closely and consider proactive engagement with API suppliers to ensure readiness

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Supporters of the proposal argue that large canisters marketed through smoke shops have fueled misuse and that stronger local restrictions are needed to reduce public access The renewed focus on nitrous oxide regulation comes as lawsuits continue to allege that manufacturers and distributors aggressively marketed these products while minimizing the risks of serious injuries, including nerve damage, paralysis, vitamin B12 deficiency, and other neurological complications

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Literature review current through: Apr 2026