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Metformin use in obese mothers is associated with improved cardiovascular profile in the offspring

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A recent review (2022) emphasizes that the available evidence is limited and that further research is urgently needed

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Among the different statistical tools, the lack-of-fit can help validating the adequacy of the model, identifying potential issues with the experimental design or data collection process and improving the model by incorporating additional terms

Schwarzlander, M., Dick, T