Symptoms typically worsen after consuming fatty foods or indigestible solids, forcing patients to adopt liquid diets or require nutritional support through feeding tubes when oral intake becomes impossible
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Drugs for those conditions already exist, and theyre often generic
The broader GLP-1 class also remains under active legal scrutiny: more than 4,400 lawsuits have been filed against Eli Lilly and Novo Nordisk in multidistrict litigation alleging failure to warn about gastroparesis and vision loss linked to existing semaglutide and tirzepatide products, though neither orforglipron nor retatrutide is named in that litigation
Sarah Whitmires affiliation has changed since the completion of the study, and since Jan 2020 she is a full-time employee of Novo Nordisk Inc