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Yet, contrary to these findings, metformin does not directly inhibit DPP-4 activity in vitro [9, 14, 16]

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Secondary findings include a 75.8% reduction in WOMAC pain scores in participants with knee osteoarthritis, a 72% prediabetes-to-normoglycemia reversal rate, and an approximately 20% reduction in LDL cholesterol attributed to glucagon-receptor-driven PCSK9 degradation

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