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Competing interests The authors declare that they have no competing interests in the manuscript

Furthermore, the majority of our studies involve acute metformin administration and so our data cannot rule out the possibility that signalling through the GLP1R might contribute more substantially to the chronic glucose-lowering actions of metformin in more severe models of hyperglycaemia

PlexusDx has no commercial relationship with Noom and runs its own protocol-based model in the GLP-1 space

Novo Nordisk filed the New Drug Application (NDA) for CagriSema in early 2026, based on positive results from the REDEFINE phase 3 trial program

The discontinuation figures are the part I keep rereading: 11.6% at 9 mg and 7.7% at 12 mg

Tirzepatide is also a once-weekly injectable, but it works on both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors