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However, another study demonstrates that IGF-IR overexpression is essential for leukemia-initiating cell activity in T-ALL [15]

(PubMed) McEvoy CT, Shorey-Kendrick LE, Milner K, et al

This enhancement results from the rapid reaction between the phenylboronic acid group and sialic acid on cancer cells 8

This is further extended by clinical finding showing that CHF is associated with marked insulin resistance, characterized by both fasting and stimulated hyperinsulinemia