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In animal experiments on such drugs, studies on rodents have found that the GLP-1RAs may promote the development of medullary thyroid carcinoma, but this effect has not been observed in non-human primates [23]

Several of these cases involved people with MCAS who were taking the drugs for obesity at the standard dose

The most recently approved type, tirzepatide [archived link], is called a dual agonist because it mimics the effects of two gut hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

Rev Diabet Stud, 11(3-4), 202-230

The delivery system for injectable versions of weight loss drugs is more complicated than for a pill

Nature (2013) 494(7436):2615