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Three clinicians, one patient, and in most clinics today zero shared visibility between them

For instance, SRT2379 was withdrawn after failing to meet efficacy expectations in a Phase I trial, highlighting unresolved issues related to tissue specificity and pathological context dependence

doi: 10.1016/j.freeradbiomed.2023.09.006 33 ZhouXZhouRRaoXHongJLiQJieXet al

Clinical studies show reductions in inflammation markers like hs-CRP by up to 54% (NIH) and improvements in oxidative stress by 73% (NIH) with regular use

This has been demonstrated in animal studies and confirmed in humans, where impaired proteasome function in adipocytes is strongly linked to insulin resistance

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