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The ability to engage in FAO also enables CSCs to withstand metabolic stress imposed by therapeutic interventions targeting glycolysis or glutaminolysis

Mol Nutr Food Res 2013;57(3):483493

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Lactate not only has a nutritional role, providing reducing power to the electron transport chain when it is oxidized to pyruvate, which is then channeled into the tricarboxylic acid (TCA) cycle, which is fully active when lactate is used as a carbon source (Jyssum, 1960

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212 Ketogenic diets are very low in carbohydrate, high in fat, and adequate in protein, and are used to treat epilepsy and obesity