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The compound was first reported in Al-Obeidi, Castrucci, Hadley, and Hruby, J Med Chem 32 (12):255561 (1989) (PMID 2555512), building on the earlier open-chain superpotent precursor [Nle, D-Phe]--MSH reported by Sawyer, Sanfilippo, Hruby, Engel, Heward, Burnett, and Hadley in PNAS 77 (10):57548 (1980) (PMID 6777774)

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However, these therapies are commonly accompanied by adverse gastrointestinal and cardiovascular effects that limit their use [12]

Rushing to higher doses frequently results in severe nausea, vomiting, and premature discontinuation

The medication has an approximate half-life of seven days, which is why doctors recommend once-weekly injections rather than daily pills

Interestingly, TruDiagnostic even 18 months ago had indicated the GLP-1 drugs were tracking very well as compared to almost everything else on being predictive of a lower epigentic age vs