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Glutamate is converted to KG, an intermediate in the TCA cycle in glutaminolysis, which activates the TCA cycle, although much remains exported by xCT in exchange for extracellular cystine [16]

Nakade, Y., Tsukamoto, K., Pappas, T

Small molecule GLP-1 agonists in the clinic Orally dosed small molecule receptor agonists of GLP-1R such as danuglipron, lotiglipron and orforglipron (Figure 1) have been discovered and have progressed into clinical trials

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