These signals recruit immune cells to the injury site, increase blood flow, and create the characteristic heat, redness, swelling, and pain we associate with inflammation
Lasa JS, Olivera PA, Danese S, Peyrin-Biroulet L
While this is part of how they help with appetite and weight, it can also lead to: Acid reflux A feeling of fullness or pressure Disrupted sleep (especially if reflux worsens at night) Even if youve been taking Akkermansia, it may not fully offset this effect because the root issue here is mechanical (slower stomach emptying) rather than purely microbial
For many of these patients who gain insulin independence post-transplant, the effect diminishes over time
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Basal changes are also possible, depending on your patterns