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Application Hospital pharmacies Injectable drug manufacturers Research laboratories Hospitals represent the largest end-user segment, accounting for approximately 60% of the market

It is naturally present in human plasma and was isolated by Loren Pickart in 1973

The LA/Ao ratio was devised by medical researchers in a 1974 study of humans, based upon the assumption that humans' normal sized LAs and Aos are proportional to each other, and so the LA/Ao ratio can indicate a reference range of normal sized human left atriums and degrees of left atrial enlargement

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