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Nonetheless, these clinical trials were underpowered to detect rare events such as suicidal ideation and self-injurious behavior, and they systematically excluded patients with psychiatric comorbidities commonly seen in clinical settings

To directly evaluate the head-to-head weight-lowering potential of semaglutide versus GLP-1MK-801, we performed single intracerebroventricular (i.c.v.) infusions of equimolar concentrations of GLP-1MK-801 or semaglutide (Fig

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Consistent sourcing, analytical verification, controlled handling procedures, and batch-level traceability all contribute to reproducible laboratory outcomes