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While this barrier protects neural tissue from toxins and pathogens, it also significantly limits the delivery of therapeutic agents to the brain

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Nat Rev Cancer 8:96775 Orrenius S, Gogvadze V, Zhivotovsky B (2007) Mitochondrial oxidative stress: implications for cell death

Here, FA mediates active targeting of the NPs to oral cancer tumors, and the disulfide bond is cleaved under high concentrations of GSH, enabling the precise release of paclitaxel at the tumor site through redox reactions, thus achieving an anti-tumor effect