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To understand the structural basis of this abnormal binding characteristic, Sack et al solved the crystal structure of the wild-type (WT) (PDB: 1I37) and T877A (PDB: 1I38) AR LBDs complexed with DHT 67

Discontinuation is typically driven by lack of perceived benefit, cost considerations, or completion of a defined protocol cycle rather than safety concerns

This lipid-lowering drug, in addition to lipid control, is used as an adjunct therapy for reducing plasma glucose levels in T2D [183]

Carrying extra weight exacerbates insulin resistance, creating a challenging loop where PCOS symptoms make weight loss difficult, and excess weight worsens the symptoms

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Ramezani A, Raj DS