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The peptide influences both endothelial nitric oxide synthase (eNOS), which produces the beneficial, vasodilating form of nitric oxide, and inducible nitric oxide synthase (iNOS), which can produce excessive amounts that contribute to inflammation and tissue damage

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A BMI of 30 and above is obese

specifically, there was no change in ZO-1 expression or vimentin stain of the EHBDs in treated mice, unlike the ex-vivo local EHBD treatment (Supplementary Fig