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It presents as a cluster of changes that often get attributed to "just getting older." Here's what to look for: Persistent Fatigue Not regular tiredness a fundamental lack of energy that doesn't improve with adequate sleep

Van Harken DR, Dixon CW, Heimberg M

Source: Chang et al., 2020 Antioxidant and Anti-Inflammatory Action Alcohol generates massive oxidative stress

This is because, without enough deep sleep, repair processes do not fully occur

Tayran H, Yilmaz E, Bhattarai P et al (2024a) ABCA7dependent neuropeptideY signalling is a resilience mechanism required for synaptic integrity in Alzheimers disease

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