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2 Long-term cardiovascular outcomes data wont be available until TRIUMPH-CVOT reports, likely in 2028 at the earliest

Because it is a triple agonist that includes glucagon, it directly stimulates lipolysis and increases resting energy expenditure, resulting in significantly greater weight loss in head-to-head phase 2 trials

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Continued loss without plateau (weeks 24-48)

For tirzepatide at the highest dose, the SURMOUNT-1 trial showed an average of 22.5% weight loss at 72 weeks, which represents one of the most significant weight loss results ever achieved with any medication

Hyperglycemia itself damages blood vessels through several mechanisms