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It involved almost 18,000 participants with excess weight or obesity and cardiovascular disease who took weekly Wegovy injections for four years while also making lifestyle changes, such as following a reduced-calorie diet and increasing physical activity

N Engl J Med 384(12):11131124 Osaka T, Endo M, Yamakawa M, Inoue S (2005) Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system

Here are this weeks picks and some further reading suggestions among the latest medical news

GLP-1 Receptor Agonism Mechanism Stimulates glucose-dependent insulin release from pancreatic -cells, reducing hyperglycaemia

Constipation : Affects approximately 324% of patients depending on the specific medication and dose, likely due to significantly slowed gastrointestinal transit time

A patient should not have to guess whether a symptom is normal, whether a dose is too high, or whether treatment should be paused