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Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease

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Its selectivity and minimal side effects make it an attractive option for individuals seeking to improve their body composition, sleep quality, and overall well-being

However, taxa associated with TMAO diverged between disease modalities