doi: 10.1097/CCO.0b013e32801195eb
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"GLP-1s require consistent administration to sustain results, and inconsistent use can lead to wide variations in blood glucose levels," says Chhaya Makhija, M.D., DipABLM
Translational studies incorporating human liver tissue are needed to validate preclinical mechanistic findings, particularly for pathways such as Pdia3/Perk/Qrich1 signaling currently demonstrated only in animal models (42)
Obesity significantly elevates the risk of conditions such as type 2 diabetes, hypertension and cardiovascular disorders, creating stronger demand for treatments capable of producing sustained weight loss and improving overall metabolic health