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These battery-powered or USB-powered devices actively cool their contents to refrigerator temperatures, typically maintaining 36 to 46 degrees Fahrenheit continuously for 8 to 24 hours on a single charge

They mimic the GLP-1 (glucagon-like peptide 1) hormone produced in the gut as a response to eating, which raises insulin production and lowers blood sugar

Phase 2 trial data showed no MACE signal but were not powered to detect cardiovascular outcomes

This reduced appetite can lead to a decrease in calorie consumption, contributing to weight loss

Probiotics can help with GI discomfort

GLP-1R is a G protein-coupled receptor