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23 A combination of these data with a meta-analysis 3 reviewing rosiglitazone use, which showed a 43% increase in the rate of myocardial infarction (p=0.003) and a 64% nonsignificant increased risk of CV death (p=0.006) in patients using the drug, ultimately compelled the FDA to take immediate action toward changing the standard requirements for documenting safety of new medications seeking approval for T2DM treatment

Action Steps for Managing Side Effects: Stay Hydrated: Dehydration can worsen nausea and is a risk factor for kidney strain when taking GLP-1s

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ALLOPURINOL IMPURITY D CRS 13

Effects of GLP-1 on forearm vasodilator function and glucose disposal during hyperinsulinemia in the metabolic syndrome

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