Roberto De Simone, plan further investigations involving direct measurements of brain pressure and comparisons among different GLP-1 medications
-cell apoptosis is mediated by a series of cascade mechanisms of the cysteine protease family, and current studies on hyperglycemia-induced -cell apoptosis have focused on the balance between the pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and the anti-apoptotic Bcl family (Bcl-2 and Bcl-xl) (Tomita, 2016), and apoptosis occurs only when the concentration of the pro-apoptotic protein Bcl-2 on the mitochondrial membrane of the intrinsic pathway exceeds the concentration of the anti-apoptotic protein
The severity ranges widely
And insulin resistance itself, when severe enough, can blunt the metabolic improvements these medications provide
On the other hand, other mediators may also be part of the pathophysiological mechanisms triggered by oxidative stress in this kind of NP, such as aquaporin-1
10.4103/IJO.IJO_2841_22 132 OConnorE