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Expected Timeline of Results Weeks 1 to 2: Appetite reduction from semaglutide begins Weeks 2 to 4: GHK-Cu initiated

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For patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of JANUVIA is 25 mg once daily