glp-1 vs sglt2 weight loss receptor agonists Recommendations for SGLT2i versus GLP-1

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1 Introduction Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two naturally occurring hormonal peptides produced in gastrointestinal tract, knowns as incretins

Maybe GLP-1 drugs seem to do everything because obesity (and high blood sugar) are broadly bad for you, and anything that reduces obesity (or high blood sugar) is broadly good for you

Phase 2 data showed 24.2% average weight loss at 48 weeks

When you eat, nutrientsparticularly carbohydrates, fats, and proteinsstimulate these L-cells to release GLP-1 into the bloodstream

The mean systolic blood pressure reduction was 5.3 mm Hg for semaglutide, 6.5 mm Hg for tirzepatide 15 mg, and 3.6 mm Hg for tirzepatide 10 mg