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Macromelanosomes have been reported in these lesions, and they are said to occur with increased frequency in lesions from patients with neurofibromatosis type 1 [27, 28]

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[1] Systematic reviews and meta-analyses of randomized controlled trials report that retatrutide produces substantial reductions in body weight in adults with obesity, with mean percentage weight loss typically between 15 and 24 percent over 48 to 72 weeks, depending on study protocols and populations

These medications slow gastric emptying and alter pancreatic hormone secretion, potentially triggering inflammation in susceptible individuals