The length of the black lines corresponds to the magnitude of the running enrichment score from GSEA
EMOTHION is the active form of GSH S-Acetyl Glutathione
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(6) I Ct, Y Sakarya, N Kirichenko, et al (2016) Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction Canadian Journal of Physiology & Pharmacology, 2016 Oct 19, Volume 95 (Issue 2), Pages 206214
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The population-level signal, however, is hard to dismiss