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Semaglutide (Ozempic/Wegovy) got FDA approval, then demand outstripped supply, so it went on the "drug shortage list." That shortage list temporarily opened a legal door for compounding pharmacies to make their own versions

In the central nervous system, GLP-1R signaling within hypothalamic circuits increases satiety and reduces food intake, ultimately promoting body weight reduction

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In addition, Nle 1 -AngIV and these shorter fragments, facilitated hippocampal synaptic connectivity via synaptogenesis [70]

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