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Beyond direct effects on reward pathways, GLP-1 receptor agonists may alter alcohol consumption through putative effects on stress response systems, including the hypothalamic-pituitary-adrenal axis

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Frias JP, Nauck MA, Van J, Kutner ME, Cui X, Benson C, Urva S, Gimeno RE, Milicevic Z, Robins D, Haupt A

It helps reduce fat accumulation by promoting healthy digestion , reducing inflammation , and balancing blood sugar levels

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Many GPCRs, including GLP-1R and GIPR, couple to the stimulatory G protein, Gs, to activate adenylyl cyclase and produce the second messenger cyclic AMP