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The primary risks include excessive blood glucose reduction, additive gastrointestinal side effects (diarrhoea, nausea, cramping), and potential drug interactions

22 Among the participants who reported any GI AEs, the vast majority experienced their first event during the doseescalation period, suggesting that the elevated prevalence of GI AEs with semaglutide versus placebo after dose escalation is primarily because of additional events being reported by participants who have previously experienced a GI AE

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Finally, the clinical studies summarized used collagen (bovine or animal sources such as fish, collagen peptides, and hydrolyzed collagen, where some test materials were commercially available products while others used multiple custom formulations), which are noted in the brief descriptions above

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