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Doses were 25, 50 and 200 mg/kg in rats and 25, 50 and 100 mg/kg in rabbits which are approximately 0.3, 0.6 and 2-times (rats) and 0.6, 1 and 2-times (rabbits) the MRHD for schizophrenia of 800 mg/day based on mg/m2 body surface area

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Evidence: Earlier studies showed HN019 reduced gut transit time and improved bowel movement frequency in some populations

And this is up from just 2 percent in the 1960s