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9B, D), which reflected elevated hippocampal intracellular calcium levels in MSG-exposed rats, previous studies have linked the high intracellular calcium levels induced by excessive glutaminergic stimulation with increased caspase activation and neuronal cell death in the pathological cascades of numerous neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), PD, and AD 8

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Karvinen S, Juppi H-K, Le G (2021) Estradiol deficiency and skeletal muscle apoptosis: possible contribution of MicroRNAs

doi: 10.1016/0006-291x(80)91238-3

As an electrophilic chemical, ITCs might react covalently with the thiol groups of (proteins and) glutathione in plants, similar to what has been demonstrated in different in vitro systems 38,77,78 as well as in insects feeding on GSL or ITC diets 79,80