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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

Iodine is essential for T3 and T4 synthesis, but both deficiency and excess can promote autoimmunity

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Dual Appetite Suppression Through Different Brain Pathways: Both peptides suppress appetite, but they do so through different receptor systems in different brain regions, allowing their effects to be additive or combined rather than redundant