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[56] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake

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Bolt S, Routledge E, Lloyd I, Chatenoud L, Pope H, Gorman SD, et al

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