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Following 6 weeks of HFD, all mice were switched to HFD supplemented with tamoxifen to induce cell GLP-1R knockdown and were maintained on this diet throughout study, resulting in a total duration of 8 weeks of HFD feeding before intervention, which results in impaired glucose tolerance, insulin secretion, and islet function, as previously established (2628)

Frequently cited work includes publications by Sikiric et al

The data set was analysed using the DAVID, ingenuity pathway analysis (IPA) and GSEA for pathway identification

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