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Matthew Hayes, a nutritional neuroscientist at the University of Pennsylvania, who has studied GLP-1 and other gut hormones since 2006, explains that these drugs work partly because they slow digestion and modulate glucose levels

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Volume expansion in obesity-related HFpEF exacerbates elevation in cardiac filling pressures that develop due to impairments in left ventricular distensibility 3 , and thus, reducing circulating volume may decrease cardiac filling pressures

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Although not relevant to mature red blood cells, this phenomenon may be important in determining the G6PD level in nucleated cells both physiologically and under stress conditions

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