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Effectiveness A 2023 JAMA Network study found that participants using tirzepatide lost an average of 25% of body fat within the first yearcompared to about 15% for semaglutide users

Because of this, many healthcare providers suggest waiting to use tirzepatide until breastfeeding is done

Food stays in the stomach longer, and this can change how it moves through the rest of the digestive tract

However, this tightly regulated process can be disrupted, leading to persistent unresolved inflammation

Initial weeks require more careful food choices and smaller portions

The more recent semaglutide trials (ADJUST T1D) reported up to 30% insulin dose reduction alongside weight loss and improved time in range