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Description

While WWP-1 has the capacity to ubiquitinate NHR-49 and has previously been implicated as an aging regulator during dietary restriction 96,97 , wwp-1 RNAi did not reproducibly stabilize steady-state NHR-49 levels within the worm as determined by western blot (Supplementary Fig

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This is an important finding related to cerebrovascular function, as cerebrovascular resistance is an index measure calculated as mean arterial pressure divided by MCAv (Thomas et al., 2021)

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The reaction is commonly known as the Ellman's assay

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