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Several metal-based nanoparticles harboring multivalent elements, such as Cu 2+ /Cu + , Mn 4+/3+ /Mn 2+ , Mo 6+ /Mo 4+ , and Ir 4+ /Ir 3+ , possess strong oxidization, and can directly react with GSH (Nie et al., 2022)

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In the rats that received GHK-Cu, the researchers found an increase in total protein and collagen synthesis greater than that of the placebo group, demonstrating that GHK-Cu is able to increase extracellular matrix accumulation in wounds in vivo .28 Are GHK-Cu copper peptides safe

It exists in cells in two states: thiol-reduced (GSH) and disulfide-oxidized (GSSG)