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These drugs induce a mean weight loss of 1.88kg and also lower blood pressure (mean: 2.46mmHg in systolic and 1.46mmHg in diastolic blood pressure).48 The EMPA-REG,49 CANVAS and CANVAS-R trials,50 conducted in patients with DM2 and high cardiovascular risk, showed empagliflozin and canagliflozin to reduce cardiovascular risk (including cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and hospital admission due to heart failure)

Tapering off Contrave is also recommended because it contains bupropion, an antidepressant that can lead to withdrawal symptoms if discontinued suddenly

We prioritize regular follow-ups to track progress, adjust treatment plans, and address any concerns or side effects

31 Buhl R, Barth H, Hugo HH, Mautner VF, Mehdorn HM

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Semaglutide mejora la sensibilidad a la insulina principalmente mediante la prdida de peso y efectos directos como estimular la secrecin de insulina dependiente de glucosa, suprimir el glucagn y retrasar el vaciamiento gstrico