Timing: Creatine is flexible
The mechanism of its pathogenesis is not fully understood, multiple parallel hits are believed to be involved, including insulin resistance, hormones secreted from the adipose tissue, nutritional factors, gut microbiota and genetic and epigenetic factors ( In recent years, more and more attention has been paid to intestinal flora and its metabolites
Smaller, more frequent intake: both food and fluids: tends to sit better and reduces nausea compared to trying to eat normal-sized meals less often
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GIP affects nutrient absorption timing, insulin secretion, and fat metabolism
J Biosci Bioeng 116(4):475479 Wang H (2013) Homocysteine induces inflammatory transcriptional signaling in monocytes