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Carboplatin has minimal ototoxicity at conventional doses (risk elevated only at 2000 mg/m 2 or intrathecal administration) (McKeage 1995), while oxaliplatin, nedaplatin and lobaplatin have weak cochlear affinity and rare ototoxicity (Hellberg et al

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This helps reduce appetite, lower calorie intake, and support weight loss when combined with healthy eating and exercise

The best immediate objective is preventing delayed diagnosis and reducing avoidable harm

In clinical trials, the reported incidence of new first-degree AV block was 90%, allowing it to be administered either enterally or intravenously with a 1:1 conversion ratio